必赢电子

陈贺 副教授
发布时间: 2023-03-29 浏览次数: 999

姓名

陈贺

职称

特聘研究员

所在部门

药必赢电子

研究方向

药物化学


办公室

药必赢电子B102

办公电话

022-83336687

电子邮箱

chenhe@tmu.edu.cn

教育背景

2012920177月 中国科必赢电子上海有机化学研究所,有机化学,博士学位

2008920126月 河北大学,化学专业,学士学位

工作经历

20227今 必赢电子,特聘研究员

2018620218月 美国西奈山伊坎医必赢电子,博士后

2017720185月 上:先┮笛蟹⒂邢薰,高级研究员

科研方向

1.基于靶向蛋白质降解技术(PROTAC),进行创新药物研发


2.针对重要疾病靶点,进行小分子抑制剂药物研发

研究成果(本人具有代表性的论著、论文及主持的科研项目)















    论文









(1)   Chen, H.#; Liu, J.#; Kaniskan, H. ?.; Wei, W. *; Jin, J.*Folate-Guided Protein Degradation by Immunomodulatory Imide Drug-Based Molecular Glues and Proteolysis Targeting Chimeras.J. Med. Chem.2021,64, 12273. (#Authors contributed equally) (IF 8.0).

(2)   Liu, J.#; Chen, H.#; Kaniskan, H. ?.; Xie, L.; Chen,X.; Jin, J.*; Wei, W. * TF-PROTACs enable targeted degradation of transcription factors. J. Am. Chem. Soc. 2021, 143, 8902. (#Authors contributed equally) (Highlighted by X-mol) (IF 16.4).

(3)   Liu, J.#; Chen, H.#; Liu, Y.; Shen,Y.; Meng, F.; Kaniskan, H. ?.; Jin, J.*; Wei, W. * Cancer selective target degradation by folate-caged PROTACs. J. Am. Chem. Soc.2021, 143, 7380. (#Authors contributed equally) (Highlighted by X-mol) (IF 16.4).


论文和专利

(4) Liu, J.#; Chen, H.#; Ma, L.; He, Z.; Wang, D.; Liu, Y.; Lin, Q.; Zhang, T.; Gray, N.; Kaniskan, H. ?.; Jin, J.*; Wei, W.* Light-Induced Control of Protein Destruction by Opto-PROTAC. Sci. Adv.2020, 6, eaay5154. (#Authors contributed equally) (Highly cited paper (top 1%) from Web of Science) (IF 15.0).

(5) Chen, H.; Liu, Z.; Lv, Y.; Tan, X.; Shen, H.; Yu, H.-Z.; Li, C.* Selective Radical Fluorination of Tertiary Alkyl Halides at Room Temperature. Angew. Chem. Int. Ed. 2017, 56, 15411. (IF 16.8).

(6) Chen, H.; Zhu, L.; Li, C.* Silver-Catalyzed Radical Carbofluorination of Unactivated Alkenes with Acetic Acid in Aqueous Solution. Org. Chem. Front.2017, 4, 565. (Organic Chemistry Frontiers HOT articles for 2017) (IF 5.5).

(7)   Liu, J.; Yu, X.; Chen, H.; Kaniskan, H. ?.; Xie, L.; Chen, X.; Jin, J.; Wei, W. TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors. J. Am. Chem. Soc. 2022, 144, 12934. (IF 16.3).

(8) Zhang, S.; Chen, H.; Zhang, C.; Yang, Y.; Popov, P.; Liu, J.; Krumm, B. E.; Cao, C.; Kim, K.; Xiong, Y.; Katritch, V.; Shoichet, B. K.; Jin, J.; Fay, J. F.; Roth, B. L. Inactive and Active State Structures Template Selective Tools for the Human 5-HT5A Receptor. Nat. Struct. Mol. Biol.2022, 29, 677. (IF 18.4).

(9) Cao, C.#; Kang, H. J.#; Singh, I.; Chen, H.; Zhang, C.; Ye, W.; Hayes, B. W.; Liu, J.; Gumpper, R. H.; Bender, B. J.; Slocum, S.; Krumm, B. E.; Lansu, K.; McCorvy, J. D.; Kroeze, W. K.; English, J. G.; DiBerto, J. F.; Olsen. R. H. J.; Huang, X-P.; Zhang, S.; Liu, Y.; Kim, K.; Karpiak, J.; Jan, L. Y.; Abraham, S. N.; Jin, J.; Shoichet, B. K. *; Fay, J. F.*; Roth, B. L.* Structure, Function and Pharmacology of Human Itch GPCRs. Nature2021, 600, 170. (IF 69.5).

(10)  Wei, J.; Meng, F.; Park, K.; Yim, H.; Velez, J.; Kumar, P.; Wang, L.; Xie, L.; Chen, H.; Shen, Y.; Teichman, E.; Wang, G.; Chen, X.; Kaniskan, H.*; Jin, J.* Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation. J. Am. Chem. Soc. 2021, 143, 15073. (IF 16.4)

(11)   Shen, Y.; Li, F.; Szewczyk, M. M.; Halabelian, L.; Chau, I.; Eram, M. S.; Dela Se?a, C.; Park, K. S.; Meng, F.; Chen, H.; Zeng, H.; Dong, A.; Wu, H.; Trush, V. V.; Mcleod, D.; Zepeda-Velázquez, C. A.; Campbell, R. M.; Mader, M. M.; Watson, B. M.; Schapira, M.; Arrowsmith, C. H.; Al-Awar, R.; Barsyte-Lovejoy, D.; Kaniskan, H. ?.; Brown, P. J.; Vedadi, M.; Jin, J. A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. J. Med. Chem. 2021, 64, 3697. (IF 8.0).

(12) Shen, Y.; Li, F.; Szewczyk, M. M.; Halabelian, L.; Park, K.-S.; Chau, I.; Dong, A.; Zeng, H.; Chen, H.; Meng, F.; Barsyte-Lovejoy, D.; Arrowsmith, C. H.; Brown, P. J.; Liu, J.*; Vedadi, M.*; Jin, J.* Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. J. Med. Chem.2020, 63, 5477. (IF 8.0).

(13) Liu, Z.; Chen, H.; Lv, Y.; Tan, X.; Shen, H.; Yu, H.-Z.; Li, C.* Radical Carbofluorination of Unactivated Alkenes with Fluoride Ions. J. Am. Chem. Soc. 2018, 140, 6169. (IF 16.4).

(14) Tan, X.; Song, T.; Wang, Z.; Chen, H.; Cui, L.; Li, C.* Silver-Catalyzed Decarboxylative Bromination of Aliphatic Carboxylic Acids. Org. Lett. 2017, 19, 1634. (IF 6.1).

(15) Zhou, S.; Song, T.; Chen, H.; Liu, Z.; Shen, H.; Li, C.* Catalytic Radical Trifluoromethylalkynylation of Unactivated Alkenes. Org. Lett. 2017, 19, 698. (IF 6.1).

(16) Cui, L.; Chen, H.; Liu, C.; Li, C.* Silver-Catalyzed Decarboxylative Allylation of Aliphatic Carboxylic Acids in Aqueous Solution. Org. Lett. 2016, 18, 2188. (IF 6.1).

(17) Zhu, L.; Chen, H.; Wang, Z.; Li, C.* Formal Fluorine Atom Transfer Radical Addition: Silver-Catalyzed Carbofluorination of Unactivated Alkenes with Ketones in Aqueous Solution. Org. Chem. Front. 2014, 1, 1299. (Organic Chemistry Frontiers HOT articles for 2014) (IF 5.5).


专利:以共同发明人获授权国际专利5项(WO2022251614A1、WO2022165185A1、WO2021016521A1、WO2020227325A1 WO2019113071A1

科研项目    


 天津医科大学杰出青年学者C类岗位项目(100万),主持,2022/7-2027/6

国家自然科学基金青年项目(项目号82204223,30万),主持,2023/1-2025/12




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